How Immunity & Mental Health are Connected: The Gut-Brain Axis

Living Alchemy • January 26, 2022

Did you know that you have more than one brain? In recent years, scientists and researchers have discovered that the bacteria in our gut acts like a “little brain” that influences not only gut health, but also cognitive health. While research is still in its infancy, scientists have discovered that mental health issues and cognitive impairment could be more complicated than just an issue in the brain. However, this also means that we may have more solutions to treat those suffering from mental health issues.


What is the Gut Microbiome?

The microbiome is vast and intricate. While it was once thought that bacteria in the gut was just responsible for aiding digestion, scientists are now realizing that the microbiome does so much more. The human microbiome is “all microorganisms in the human body and their respective genetic material”.1 There are about 100 trillion bacteria in our intestines that outnumber our own cells ten to one.2 The main role these bacteria play in our gastrointestinal tract is aiding digestion, breaking down nutrients and working with the immune system, as well as communicating with the brain.3


The Gut-Brain Axis

Communication between the gut microbiome and the brain is called the Gut-Brain Axis. Scientists have discovered that the human gastrointestinal tract has its own neural network with nerve cells lining the entire tract from mouth to rectum.3 In addition, the gut produces neurotransmitters that influence brain chemistry. For example, serotonin, a neurotransmitter largely responsible for regulating depression and anxiety, is produced mainly in the gut. Conversely, gut bacteria responds to these neurotransmitters just like the brain does which means that the brain influences our gut bacteria as well.2 If the gut is happy, the brain will be happy and vice versa.


The connection between gut and brain can have a profound impact on physical and mental health. Inflammation in the gut can lead to holes in the intestinal lining called leaky gut. The immune system responds to gut inflammation by attacking the digestive tract causing even more holes in the intestinal lining. Food particles and pathogens can then seep into the bloodstream, enter the central nervous system, and even pass through the blood-brain barrier.1 Scientists have discovered that this process can trigger autoimmune diseases.4 Furthermore, chronic inflammation and an overactive immune system has been correlated with mental health disorders.1 Our gastrointestinal system sends signals to the brain that can alter mood and can cause disorders such as bipolar, depression, and schizophrenia.5 Not only that, but stress can change the bacterial makeup of the gut. making us susceptible to illness and, like a feedback loop, more susceptible to mental health issues. 2


What Can You Do?

Changes in dietary habits can mitigate autoimmune conditions and even may reverse them.3 Your microbiome is largely influenced by what you are consuming. Eating clean, organic, and non-processed foods and supplements, while minimizing added sugar and alcohol consumption, can profoundly improve your gut health. Scientists are also discovering that various forms of therapy, such as cognitive behavioral therapy, can calm the mind and ease gut issues.


One exciting discovery is that scientists have found that probiotics can play a huge role in healing the gut and boosting cognitive health. While more research needs to be conducted, scientists are finding that probiotics help reduce inflammation, prevent neural dysfunction, and can reduce cortisol levels thereby decreasing anxiety and depression. In fact, probiotics may have a similar effect as antidepressants! 1

Living Alchemy is committed to formulating the best clean supplements for your gut and full body health.

1. Clapp, Megan. Sept 15, 2017. Gut microbiota’s effect on mental health: The gut-brain axis. NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/ Accessed April 17, 2020

2. Carpenter, Siri. September 2012. That gut feeling. American Psychological Association. https://www. apa.org/monitor/2012/09/gut-feeling Accessed April 17, 2020.

3. John Hopkins Medicine. The Brain-Gut Connection. John Hopkins Medicine. https://www. hopkinsmedicine.org/health/wellness-and-prevention/the-brain-gut-connection Accessed April 18, 2020.

4. Wekerle, Hartmut. December 2016. The gut–brain connection: triggering of brain autoimmune disease by commensal gut bacteria. Rheumatology. https://academic.oup.com/rheumatology/article/55/ suppl_2/ii68/2892202 Accessed April 17, 2020.

5. McQuillan, Susan. Nov 18, 2018. The Gut Brain Connection: How Gut Health Affects Mental Health. PSYCOM. https://www.psycom.net/the-gut-brain-connection Accessed April 18, 2020.

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